Vitamin D is known to suppress adaptive immune response by several mechanisms. One of which is carried out through shifting T cell differentiation in favor of T helper (Th) 2 instead of Th1. Unlike Th1, which specializes in inflammation and killing of bacteria & protozoa, Th2 specializes in anti-inflammation, killing of helminthes, and type 1 hypersensitivity. Thus, does its use promote allergic reaction?
The answer is no. This is because, even though it favors Th2 differentiation, it also inhibits development of mast cells, the key player of allergic reaction. Hence, the function of Th2 that is augmented is only the anti-inflammatory one. This property leads to its use in treating asthma.
References:
The answer is no. This is because, even though it favors Th2 differentiation, it also inhibits development of mast cells, the key player of allergic reaction. Hence, the function of Th2 that is augmented is only the anti-inflammatory one. This property leads to its use in treating asthma.
References:
- Abbas AK, Lichtman AH, Pillai S. Cellular and molecular immunology. 6th ed. Philadelphia: Saunders; 2007. p. 315.
- Sandhu MS, Casale TB. The role of vitamin D in asthma. Ann Allergy Asthma Immunol 2010;105:191-9.
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